Abstract: Epilepsy affects three million patients in the United States. In many patients with pharmacologically refractory seizures, the only effective treatment is the neurosurgical resection of abnormally synchronized hyperexcitable brain regions—the seizure onset zone. Resection carries a risk of damaging important cognitive functions, and thus creating an effective non-resective option is critical to the welfare of millions of patients.
It is now believed that the future of epilepsy research lies in building an implantable device that prevents the brain from going into a hyperactive state, similar to how a pacemaker controls abnormal heart rhythms. The implanted device should monitor the neural activity in real-time and then apply electrical stimulation designed to modulate the connectivity of the seizure network adaptively and selectively. In this presentation, we propose a paradigm to capture the dynamic, frequency dependent connectivity of the brain from real-time monitoring of the brain using ECoG (i.e., ElectroCorticoGraphy) and then identifying the “optimal” stimulation parameters to modulate the connectivity with temporal and spatial precision. In particular, we will demonstrate how we leverage from directed information, detection, and estimation to determine ideal stimulation protocols and develop a roadmap for reparative therapies.
Behnaam Aazhang received his B.S. (with highest honors), M.S., and Ph.D. degrees in Electrical and Computer Engineering from University of Illinois at Urbana-Champaignin 1981, 1983, and 1986, respectively. From 1981 to 1985, he was a Research Assistant in the Coordinated Science Laboratory, University of Illinois. In August 1985, he joined the faculty of Rice University, Houston, Texas, where he is now the J.S. Abercrombie Professor and Chair in the Department of Electrical and Computer Engineering. In addition, Dr. Aazhang holds an Academy of Finland Distinguished Professor Programme (FiDiPro) working with the Center for Wireless Communication (CWC) at the University of Oulu, Oulu, Finland. His research interests are in the areas of communication theory, information theory, signal processing, and their applications to wireless communication with a focus on the interplay of communication systems and networks; including network coding, user cooperation spectrum sharing, and opportunistic access. Signal processing, information processing, and their applications to neuro-engineering with a focus on the real-time closed-loop stabilization of neuronal systems to mitigate disorders such as epilepsy, Parkinson, tremors, depression, and obesity. He is a Fellow of IEEE, a member of the Center for Multimedia Communication (CMC) at Rice.